- The film is based on the 2015 novel of the same name by Jessica Knoll.
- In August 2015, it was announced Lionsgate had acquired film rights to Luckiest Girl Alive by Jessica Knoll.
- Principal photography began in June 2021 in Toronto, Canada, and was completed in September 2021 in New York City, USA.
- Luckiest Girl Alive was released in select cinemas on September 30, 2022, before its streaming release on October 7, 2022, by Netflix.