- No One Will Save You was written on spec by Brian Duffield in 2019. In April 2021 20th Century Studios acquired the spec script No One Will Save You.
- On an estimated budget (before tax incentives) of $22.8 million, principal photography took place in New Orleans from April to June 2022.
- Visual effects will be provided by DNEG. Joseph Trapanese composed the score.
- No One Will Save You premiered in New York and Los Angeles theaters on September 19, 2023, and was later released by 20th Century Studios as a Hulu original film in the United States on September 22. It was aired on Star+ in Latin America and Disney+ in other territories the same day.