- The film serves as a prequel to Pet Sematary (2019), which in turn was based on the 1983 novel of the same name by Stephen King.
- The film was officially announced in February 2021. Principal photography took place in Montreal in August 2021, with some scenes being shot at John Abbott College.
- The entire film is supposed to be based on the memories of Jud Crandall, which are given in the book, told to Louis Creed, under different circumstances.
- Pet Sematary: Bloodlines premiered at Fantastic Fest on September 23, 2023. It was released by Paramount+ on October 6, 2023, in the United States, Canada, and Latin America, and the following day in other territories.